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Datum nieuwsfeit: 01-02-2007

( BW)(IPSEN)(IPN.PA) Ipsen's Full Year 2006 Sales

    Pharmaceutical Writers/Business Editors

    PARIS--(BUSINESS WIRE)--Feb. 1, 2007--Ipsen (Paris:IPN):

    --  Solid Growth of Drug Sales : +7.6%

    --  Strong and Continued Dynamics in Strategic Targeted
        Therapeutic Areas: +13.4%

    --  Strong Growth Outside the Five Major Western European
        Countries: +19.3%

    --  Group Sales Growth of +6.8% for the Full Year 2006, in Line
        with Objectives

Ipsen (Paris:IPN) reported today its sales for the full year 2006.

                 Unaudited IFRS Consolidated sales (1)

-0-
*T
(in million euros)                              2006   2005  % change
---------------------------------------------- ------ ------ ---------
 Total Drug Sales                              834.6  775.9      +7.6%
---------------------------------------------- ------ ------ ---------
 of which:
---------------------------------------------- ------ ------ ---------
     Targeted Therapeutic Areas                443.8  391.2     +13.4%
---------------------------------------------- ------ ------ ---------
     Primary care                              386.6  377.7      +2.4%
---------------------------------------------- ------ ------ ---------
 Drug-related Sales (2)                         27.1   31.2    (13.3)%
---------------------------------------------- ------ ------ ---------
 Group Sales                                   861.7  807.1      +6.8%
---------------------------------------------- ------ ------ ---------
*T

    Full year 2006 sales highlight

    For the full year 2006, Group sales reached EUR 861.7 million, up
6.8% year-on-year (full year 2005, EUR 807.1 million) driven by strong
growth of the specialist care products in Ipsen's Targeted Therapeutic
Areas (oncology, endocrinology, neuromuscular disorders), with sales
up 13.4% year-on-year, further accelerating growth compared to last
year's performance of +10.4%. This performance was driven notably by
the endocrinology franchise, with sales up 23.2% year-on-year and by
the neuromuscular disorders franchise, with sales up 22.5%
year-on-year. All Primary Care products showed solid growth, except
Ginkor Fort(R) which continued to suffer from cost-containment
measures enforced in February 2006(3) by the French Government. The
other primary care products grew by 9.0% year-on-year, driven notably
by the good performance of the gastroenterology franchise in Asia and
Eastern Europe, continued growth of Tanakan(R) particularly in Russia
and selected Eastern Europe countries, and continued strong
performance of Nisis(R) and Nisisco(R) in France. Overall, drug sales
posted a solid 7.6% growth year-on-year, while drug related activities
decreased 13.3% year-on year, due mostly to lower sales of active
ingredients, mainly the Ginkgo biloba extract (EGb 761(R)) and to
lower sales from Linnea, a non-strategic botanical extract
manufacturing and trading activity.

    Sales in Major Western European countries reached EUR 551.7
million, a slight 0.8% increase over last-year. The performance in
these countries has been negatively impacted by price cuts and the
Ginkor Fort(R) volume decrease that resulted from the French
government's decision to reduce its reimbursement rate, nearly
offsetting a solid underlying volume growth in the rest of the product
portfolio. In Other European countries, sales reached EUR 184.8
million, up 18.5% in 2006, while in the Rest of the World, sales
amounted to EUR 125.2 million, up 20.5% compared with 2005. In these
last two areas, growth was driven by endocrinology products and by
Dysport(R). Overall, sales outside the Major Western European
Countries grew by 19.3% year-on-year.

    Commenting on the performance in 2006, Jean-Luc Belingard,
Chairman and Chief Executive Officer of Ipsen, stated: "We are pleased
to report a 7.6% increase in our drug sales despite the challenging
environment for our industry. In this context, Ipsen's top line growth
reached 6.8%, in line with the objectives we set for the Group one
year ago. This sound performance illustrates the quality of Ipsen's
portfolio of molecules and of its international footprint and market
coverage. On this basis, we confirm our 6.5% to 7.5% sales growth
objective in 2007 before the impact of a future price reduction in
France of Tanakan(R) following the statements made by the French
Health Ministry on October 25, 2006 about the class of
vasodilatators." Jean-Luc Belingard added: "The international
performance of our specialist care franchise (oncology, endocrinology
and neuromuscular disorders) in 2006 further validates our strategic
focus and is a strong foundation for the company's future growth. We
are also pleased with the resilience our primary care products have
shown in a very difficult environment. Since its listing a year ago,
the Company has delivered on all its strategic and financial
objectives. In 2007, Ipsen will continue its efforts to rigorously
execute its strategy to grow its top line and profits in its
specialist care business by providing innovative drug therapy, to
optimize its returns in its primary care activity through selected
product life cycle management and focused investments and to globalise
through active geographical expansion policy."

    About Ipsen

    Ipsen is a European pharmaceutical group with over 20 products on
the market and a total worldwide staff of nearly 4 000. The company's
development strategy is based on a combination of products in targeted
therapeutic areas (oncology, endocrinology and neuromuscular
disorders) which are growth drivers and primary care products which
contribute significantly to its research financing. This strategy is
also supported by an active policy of partnerships. The location of
its four R&D centres (Paris, Boston, Barcelona, London) gives the
Group a competitive edge in gaining access to leading university
research teams and highly qualified personnel. In 2005, Research and
Development expenditure reached EUR 169.0 million, i.e. 20.9% of
consolidated sales, which amounted to EUR 807.1 million in the Group's
pro forma accounts set up according to the IFRS. Nearly 700 people in
R&D are dedicated to the discovery and development of innovative drugs
for patient care. Ipsen's shares are traded on Segment A of Eurolist
by Euronext(TM) (stock code: IPN, ISIN code: FR0010259150). Ipsen's
Internet website is www.ipsen.com.

    Forward-looking statements

    The forward-looking statements and targets contained herein are
based on Ipsen's management's current views and assumptions. Such
statements involve known and unknown risks and uncertainties that may
cause actual results, performance or events to differ materially from
those anticipated herein.

    Ipsen expressly disclaims any obligation or undertaking to update
or revise any forward-looking statements, targets or estimates
contained in this press release to reflect any change in events,
conditions, assumptions or circumstances on which any such statements
are based unless so required by applicable law. Ipsen's business is
subject to the risk factors outlined in its information documents
filed with the French Autorite des Marches Financiers.

                               APPENDIX

    Comparison of consolidated sales in the fourth quarters and full
years 2006 and 2005

-0-
*T
  Unaudited IFRS
   Consolidated            4th quarter               12 months
      Sales(4)
                     ----------------------- -------------------------
(in thousand euros)     2006     2005      %    2006     2005        %
-------------------- -------- -------- ----- -------- -------- -------
Total Drug Sales     204,143  193,888  +5.3% 834,583  775,877    +7.6%
-------------------- -------- -------- ----- -------- -------- -------
of which:
-------------------- -------- -------- ----- -------- -------- -------
  Targeted
   Therapeutic Areas 107,242   98,287  +9.1% 443,806  391,202   +13.4%
-------------------- -------- -------- ----- -------- -------- -------
  Primary care        95,596   93,986  +1.7% 386,580  377,654    +2.4%
-------------------- -------- -------- ----- -------- -------- -------
Drug-related
 Sales(5)              6,349    6,336  +0.2%  27,093   31,237  (13.3)%
-------------------- -------- -------- ----- -------- -------- -------
 Group Sales         210,492  200,224  +5.1% 861,676  807,114    +6.8%
-------------------- -------- -------- ----- -------- -------- -------
*T

    Note: Since the Group sold its primary care business in Spain
(except Tanakene(R)) in October 2005, the Group is presenting this
business as a "discontinued operation" retroactively from 1
January 2005 in its consolidated financial statements. Accordingly,
the consolidated sales figures for the fourth quarter and full year
2005 do not include sales for this activity.

    Fourth quarter of 2006 sales highlights

    For the fourth quarter of 2006, Group sales reached EUR 210.5
million, up 5.1% year-on-year (fourth quarter 2005, EUR 200.2 million)
driven by Targeted Therapeutic Areas growing 9.1% year on year, led by
endocrinology sales which grew 19.9% year-on-year. Primary care
products grew by 1.7% year-on-year, driven notably by a good
performance in Asia, Central and Eastern Europe and Latin America,
despite a slowdown in Major Western European countries. Sales of
Ginkor Fort(R) continued to suffer from French Government measures
enforced in February 2006 (reduction of its reimbursement rate from
35% to 15% as well as a 15% price reduction on the entire veinotonic
class of drugs).

    Excluding Ginkor Fort(R), Group sales rose 8.4% year-on-year in
the fourth quarter of 2006.

    2006 sales highlights

    For the full year 2006, consolidated Group sales reached EUR 861.7
million, up 6.8% year-on-year (6.7% excluding foreign exchange
impacts). Drug sales posted a solid 7.6% growth year-on-year, driven
by Targeted Therapeutic Areas which grew by 13.4%, further
accelerating growth year on year, while primary care drug sales only
grew by 2.4% in the same period, being negatively affected by slow
sales of Ginkor Fort(R) in France. This solid growth in drug sales was
hampered by slow sales of drug-related activities (active ingredients
and raw materials) which decreased by 13.3% year-on year, due to lower
sales of active ingredients, mainly the Gingko biloba extract (EGb
761(R)) and to lower sales from Linnea, a non-strategic botanical
extract manufacturing and trading activity.

    For the full year 2006, volumes grew by 9.1%, with price decreases
negatively impacting Ipsen's consolidated sales growth by 2.4 points,
representing EUR 19.4 million.

    Excluding Ginkor Fort(R), Group sales rose 9.9% year-on-year in
2006.

    Sales by therapeutic areas

    The following table shows sales by therapeutic areas for the
fourth quarters and full years 2006 and 2005:

-0-
*T
                          4th quarter                12 months
                   ------------------------- -------------------------
(in thousand
 euros)             2006     2005       %     2006     2005       %
------------------ -------- -------- ------- -------- -------- -------
Products in
 targeted
 therapeutic areas
------------------ -------- -------- ------- -------- -------- -------
- Oncology          53,544   51,341     4.3% 222,039  210,728     5.4%
------------------ -------- -------- ------- -------- -------- -------
- Endocrinology     27,331   22,795    19.9% 108,448   87,996    23.2%
------------------ -------- -------- ------- -------- -------- -------
- Neuromuscular
 disorders          26,367   24,151     9.2% 113,319   92,478    22.5%
------------------ -------- -------- ------- -------- -------- -------
         Sub-total 107,242   98,287     9.1% 443,806  391,202    13.4%
------------------ -------- -------- ------- -------- -------- -------
Primary care
 products
------------------ -------- -------- ------- -------- -------- -------
- Gastroenterology  39,075   35,533    10.0% 157,430  141,075    11.6%
------------------ -------- -------- ------- -------- -------- -------
- Cognitive
 disorders          34,162   30,015    13.8% 129,882  120,960     7.4%
------------------ -------- -------- ------- -------- -------- -------
- Cardiovascular    22,359   28,438  (21.4)%  99,268  115,619  (14.1)%
------------------ -------- -------- ------- -------- -------- -------
         Sub-total  95,596   93,986     1.7% 386,580  377,654     2.4%
------------------ -------- -------- ------- -------- -------- -------
Other therapeutic
 areas
------------------ -------- -------- ------- -------- -------- -------
- Other drugs        1,305    1,615  (19.2)%   4,197    7,021  (40.2)%
------------------ -------- -------- ------- -------- -------- -------
         Sub-total   1,305    1,615  (19.2)%   4,197    7,021  (40.2)%
------------------ -------- -------- ------- -------- -------- -------
Total drug sales   204,143  193,888     5.3% 834,583  775,877     7.6%
------------------ -------- -------- ------- -------- -------- -------
Drug related sales   6,349    6,336     0.2%  27,093   31,237  (13.3)%
------------------ -------- -------- ------- -------- -------- -------
Group Sales        210,492  200,224     5.1% 861,676  807,114     6.8%
------------------ -------- -------- ------- -------- -------- -------
*T

    For the full year 2006, drug sales reached EUR 834.6 million,
representing 96.9% of the Group's consolidated sales (96.1% in 2005),
up 7.6% year-on-year (or 7.5% excluding foreign exchange impacts).
Drug-related sales amounted to EUR 27.1 million in 2006, down 13.3%
year-on-year (12.8% excluding foreign exchange impacts).

    Products in targeted therapeutic areas

    For the fourth quarter of 2006, sales of products in the Group's
targeted therapeutic areas reached EUR 107.2 million, up 9.1%
year-on-year (fourth quarter 2005, EUR 98.3 million).

    For the full year 2006, sales of products in the Group's targeted
therapeutic areas reached EUR 443.8 million, up 13.4% year-on-year
(EUR 391.2 million in 2005), representing 51.5% of the Group's
consolidated sales, against 48.5% a year earlier.

    --  In oncology, sales reached EUR 222.0 million, up 5.4%
        year-on-year (EUR 210.7 million for 2005) despite negative
        administrative measures impacting Decapeptyl(R) prices mainly
        in Italy, Poland and Belgium. Volume growth year-on-year
        reached 8.6%.

    --  In endocrinology, sales reached EUR 108.4 million, up 23.2%
        year-on-year (EUR 88.0 million for 2005). This performance was
        driven by sales of Somatuline(R), up 12.8% year-on-year, and
        the successful performance of NutropinAq(R) in several markets
        three years after its first launch, with sales totalling 13.6%
        of endocrinology sales at the end of December 2006 against
        6.5% a year earlier.

    --  In neuromuscular disorders, sales reached EUR 113.3 million in
        2006, up 22.5% year-on-year (EUR 92.5 million for 2005) driven
        by Dysport(R) sales in the United Kingdom, Eastern and Central
        Europe, South Korea and Latin America.

    Primary care products

    For the fourth quarter of 2006, sales of primary care products
reached EUR 95.6 million, up 1.7% year-on-year (fourth quarter 2005,
EUR 94.0 million).

    For the full year 2006, sales of primary care products reached EUR
386.6 million, up 2.4% year-on-year (EUR 377.7 million in 2005),
impacted by the poor performance of the sales of Ginkor Fort(R) in
France. Excluding Ginkor Fort(R), sales of primary care products
reached EUR 344.9 million, up 9.0% year-on-year (EUR 316.5 million in
2005). This growth was fuelled mainly by strong performance of
Nisis(R)/Nisisco(R) in France, and of Tanakan(R) and gastro-enterology
products in China and in Eastern and Central Europe.

    --  In gastroenterology, sales reached EUR 157.4 million, up 11.6%
        year-on-year (EUR 141.1 million in 2005), driven by sales of
        Smecta(R) in France, China, Vietnam, Eastern and Central
        Europe, by sales of Forlax(R) in Italy, France and China, and
        by sales of Fortrans(R) in Poland and Russia.

    --  In the cognitive disorders area, sales reached EUR 129.9
        million, up 7.4% year-on-year (EUR 121.0 million in 2005),
        sustained by sales growth of Tanakan(R).

    --  In the cardiovascular area, sales amounted to EUR 99.3
        million, down 14.1% year-on-year (EUR 115.6 million in 2005),
        mainly due to the poor performance of Ginkor Fort(R) sales in
        France. Sales of this product suffered from the 15% price cut
        enforced on 1 February 2006 by the French Government, as well
        as from a volume decrease linked to the reduction of its
        reimbursement rate by the French Social Security to 15% from
        35%, and the decision by some of the private insurance
        companies not to continue reimbursement of Ginkor Fort(R).
        Sales in the cardiovascular area were also affected in 2006 by
        the impact of the first year of the licence agreement signed
        with Recordati in 2005, under which the Group granted the
        distribution of Tenstaten(R) to Recordati while continuing to
        supply the product. Higher volumes sold following the start of
        distribution by Recordati partly offset the price decrease of
        Tenstaten(R), thus limiting the overall negative impact on
        sales to EUR 5.5 million year-on-year, despite a corresponding
        negative price impact of EUR 9.0 million. Nisis(R) and
        Nisisco(R), with a 22.0% sales growth year-on-year, continued
        to show strong performance.

    Other therapeutic areas

    For the full year 2006, other therapeutic areas generated sales of
EUR 4.2 million, down 40.2% year-on-year (EUR 7.0 million in 2005),
due to the decision of the Group to withdraw from market some
non-strategic products in Eastern Europe.

    Drug-related activities

    For the full year 2006, drug-related sales (active ingredients and
raw materials) were down 13.3% to EUR 27.1 million, due to lower sales
of active ingredients, mainly the Ginkgo biloba extract (EGb 761(R)).
This activity accounted for 3.1% of the Group's total sales, against
3.9% a year earlier.

    Sales by product

    Group sales by product for the fourth quarters and full years 2006
and 2005 were as follows:

-0-
*T
                          4th quarter                12 months
                   ------------------------- -------------------------
(in thousand
 euros)             2006     2005       %     2006     2005       %
------------------ -------- -------- ------- -------- -------- -------
- Decapeptyl(R)
 (1)                53,521   51,305     4.3% 221,925  210,606     5.4%
------------------ -------- -------- ------- -------- -------- -------
- Tanakan(R)        34,162   30,015    13.8% 129,882  120,960     7.4%
------------------ -------- -------- ------- -------- -------- -------
- Dysport(R) (1)    26,367   24,151     9.2% 113,319   92,478    22.5%
------------------ -------- -------- ------- -------- -------- -------
- Somatuline(R)
 (1)                22,423   20,420     9.8%  92,222   81,751    12.8%
------------------ -------- -------- ------- -------- -------- -------
- Smecta(R)         19,054   16,244    17.3%  80,341   67,465    19.1%
------------------ -------- -------- ------- -------- -------- -------
- Ginkor Fort(R)     8,809   14,226  (38.1)%  41,700   61,162  (31.8)%
------------------ -------- -------- ------- -------- -------- -------
- Forlax(R)         11,975   11,183     7.1%  46,303   42,771     8.3%
------------------ -------- -------- ------- -------- -------- -------
- Nisis et
 Nisisco(R)         12,030   11,005     9.3%  50,661   41,525    22.0%
------------------ -------- -------- ------- -------- -------- -------
- NutropinAq(R)
 (1)                 4,428    2,134   107.5%  14,728    5,740   156.6%
------------------ -------- -------- ------- -------- -------- -------
- Other products    11,375   13,207  (13.9)%  43,502   51,419  (15.4)%
------------------ -------- -------- ------- -------- -------- -------
Total drug sales   204,143  193,888     5.3% 834,583  775,877     7.6%
------------------ -------- -------- ------- -------- -------- -------
Drug related sales   6,349    6,336     0.2%  27,093   31,237  (13.3)%
------------------ -------- -------- ------- -------- -------- -------
Group Sales        210,492  200,224     5.1% 861,676  807,114     6.8%
------------------ -------- -------- ------- -------- -------- -------
*T

    (1) Peptide- or protein-based products

    --  Decapeptyl(R) - For the fourth quarter of 2006, Decapeptyl(R)
        sales reached EUR 53.5 million, up 4.3% year-on-year (fourth
        quarter 2005, EUR 51.3 million). For the full year 2006, sales
        of Decapeptyl(R) reached EUR 221.9 million, up 5.4%
        year-on-year (EUR 210.6 million in 2005). Negative price
        movements reduced sales by 3.2 points but were more than
        offset by strong volume growth in Germany, the United Kingdom,
        Ireland, Greece and China as well as in Eastern and Central
        Europe.

    --  Tanakan(R) - For the fourth quarter of 2006, Tanakan(R) sales
        reached EUR 34.2 million, up 13.8% year-on-year (fourth
        quarter 2005, EUR 30.0 million). For the full year 2006, sales
        of Tanakan(R) reached EUR 129.9 million, up 7.4% year-on-year
        (EUR 121.0 million in 2005), notably driven by sales in China
        and in Central and Eastern Europe. France accounted for 70.8%
        of total Tanakan(R) sales in 2006 compared with 73.2% a year
        earlier.

    --  Dysport(R) - For the fourth quarter of 2006, Dysport(R) sales
        reached EUR 26.4 million, up 9.2% year-on-year (fourth quarter
        2005, EUR 24.2 million) reflecting a more normalised level of
        sales after three strong quarters. For the full year 2006,
        sales reached EUR 113.3 million, up 22.5% year-on-year (EUR
        92.5 million in 2005). This growth was especially fuelled by
        double digit growth in Latin America, Central and Eastern
        Europe, South Korea, the United Kingdom and in most other
        markets.

    --  Somatuline(R) - For the fourth quarter of 2006, Somatuline(R)
        sales reached EUR 22.4 million, up 9.8% year-on-year (fourth
        quarter 2005, EUR 20.4 million). For the full year 2006, sales
        of Somatuline(R) reached EUR 92.2 million, up 12.8%
        year-on-year (EUR 81.8 million in 2005), driven mainly by
        France, Spain, Germany, Scandinavia and Central and Eastern
        Europe.

    --  Smecta(R) - For the fourth quarter of 2006, Smecta(R) sales
        reached EUR 19.1 million, up 17.3 % year-on-year (fourth
        quarter 2005, EUR 16.2 million). For the full year 2006, sales
        of Smecta(R) reached EUR 80.3 million, up 19.1% year-on-year,
        or 18.7% excluding foreign exchange impacts (EUR 67.5 million
        in 2005), due to strong growth in France, China and Central
        and Eastern Europe.

    --  Ginkor Fort(R) - For the fourth quarter of 2006, Ginkor
        Fort(R) sales amounted to EUR 8.8 million, down 38.1%
        year-on-year (fourth quarter 2005, EUR 14.2 million). For the
        full year 2006, sales of Ginkor Fort(R) - mainly in France -
        stood at EUR 41.7 million, down 31.8% year-on-year (EUR 61.2
        million in 2005). As explained above, the product suffered
        from the decision taken by the French Government to reduce
        both its price and its reimbursement rate by the French Social
        Security on 1 February 2006.

    --  Forlax(R) - For the fourth quarter of 2006, Forlax(R) sales
        reached EUR 12.0 million, up 7.1% year-on-year (fourth quarter
        2005, EUR 11.2 million). For the full year 2006, sales of
        Forlax(R) amounted to EUR 46.3 million, up 8.3% year-on-year
        (EUR 42.8 million in 2005) supported by solid growth in China,
        France and Italy.

    --  Nisis(R) and Nisisco(R) - For the fourth quarter of 2006,
        Nisis(R) and Nisisco(R) sales reached EUR 12.0 million, up
        9.3% year-on-year (fourth quarter 2005, EUR 11.0 million). For
        the full year 2006, sales of Nisis(R) and Nisisco(R) amounted
        to EUR 50.7 million, up 22.0% year-on-year (EUR 41.5 million
        in 2005). Nisis(R) and Nisisco(R) performed well above the
        market despite high competitive pressure.

    --  NutropinAq(R) - For the fourth quarter of 2006, NutropinAq(R)
        sales reached EUR 4.4 million, more than doubling year-on-year
        (fourth quarter 2005, EUR 2.1 million). For the full year
        2006, sales of NutropinAq(R) reached EUR 14.7 million (EUR 5.7
        million in 2005). As expected, this product is highly
        contributing to the Group's growth in its third year of
        commercialisation.

    --  Testim(R) - After launches in Germany, the United Kingdom,
        Benelux, Scandinavia and Spain in 2005 and in Portugal, Italy
        and Greece in 2006, sales of Testim(R) remain below Group
        expectations, with slower overall market growth and lower than
        expected market penetration of gels in the territories where
        it is marketed. Furthermore, difficulties in obtaining
        reimbursement status in certain major European countries, such
        as Italy, have impacted sales development.

    --  With sales of Decapeptyl(R), Dysport(R), Somatuline(R) and
        NutropinAq(R), Ipsen's peptide- or protein-based products
        sales reached EUR 442.2 million in 2006, representing 51.3% of
        Group consolidated sales, up 13.2% year-on-year (in 2005,
        sales stood at EUR 390.6 million, representing 48.4% of the
        Group's consolidated sales).

    Sales by geographical region

    Group sales by geographical region for the fourth quarters and
full years 2006 and 2005 were as follows:

-0-
*T
                           4th quarter               12 months
                     ------------------------ ------------------------
(in thousand euros)   2006     2005      %     2006     2005      %
-------------------- -------- -------- ------ -------- -------- ------
- France              92,648   92,935  (0.3)% 358,666  360,908  (0.6)%
-------------------- -------- -------- ------ -------- -------- ------
- Spain               13,683   12,956    5.6%  53,099   52,005    2.1%
-------------------- -------- -------- ------ -------- -------- ------
- Italy               15,285   15,423  (0.9)%  66,414   65,980    0.7%
-------------------- -------- -------- ------ -------- -------- ------
- Germany              9,513    8,630   10.2%  40,279   39,462    2.1%
-------------------- -------- -------- ------ -------- -------- ------
- United Kingdom       8,751    7,805   12.1%  33,216   28,932   14.8%
-------------------- -------- -------- ------ -------- -------- ------
Major Western
 European countries  139,880  137,749    1.5% 551,674  547,287    0.8%
-------------------- -------- -------- ------ -------- -------- ------
Other European
 countries            43,696   37,796   15.6% 184,800  155,893   18.5%
-------------------- -------- -------- ------ -------- -------- ------
- Asia                13,116   10,565   24.1%  67,184   52,087   29.0%
-------------------- -------- -------- ------ -------- -------- ------
- North America           99             0.0%      99             0.0%
-------------------- -------- -------- ------ -------- -------- ------
- Other countries in
 the rest of the
 world                13,701   14,114  (2.9)%  57,919   51,847   11.7%
-------------------- -------- -------- ------ -------- -------- ------
Rest of the world     26,916   24,679    9.1% 125,202  103,934   20.5%
-------------------- -------- -------- ------ -------- -------- ------
Group Sales          210,492  200,224    5.1% 861,676  807,114    6.8%
-------------------- -------- -------- ------ -------- -------- ------
*T

    --  For the fourth quarter of 2006, sales generated in Major
        Western European countries amounted to EUR 139.9 million, up
        1.5% year-on-year (fourth quarter of 2005, EUR 137.7 million).
        For the full year 2006, sales in Major Western European
        Countries reached EUR 551.7 million, up 0.8% year-on-year (EUR
        547.3 million in 2005). The growth in volume (up EUR 21.5
        million, or +3.9%) mainly stemmed from the United Kindgom,
        Italy, Spain and France but was penalized by negative price
        impacts in Italy, Spain and France totalling EUR 17.2 million.
        In France, negative price effects were mostly due to the
        impact of the first year of the Tenstaten(R) licence agreement
        granted to Recordati as described above, and to the Ginkor
        Fort(R) price reduction. In Germany, the strong 18.4% growth
        in drug sales year-on-year was almost offset by the 23.0%
        decline in drug-related sales.

    --  In Other European countries, sales for the fourth quarter of
        2006 reached EUR 43.7 million, up 15.6% year-on-year (fourth
        quarter 2005, EUR 37.8 million). For the full year 2006, sales
        reached EUR 184.8 million, up 18.5% year-on-year (EUR 155.9
        million in 2005). Other European countries confirmed their
        good performance (Central and Eastern Europe, Belgium, Greece,
        Scandinavia) despite negative price impacts in Poland,
        Romania, Belgium and Lithuania.

    --  In the Rest of the World, sales for the fourth quarter of 2006
        reached EUR 26.9 million, up 9.1% year-on-year (fourth quarter
        2005, EUR 24.7 million), indicating a slow down in sales in
        South America, notably in Brazil. For the full year 2006,
        sales reached EUR 125.2 million, up 20.5% year-on-year (EUR
        103.9 million in 2005), driven by sales in China, Latin
        America, South Korea and Australia.

    Share Buyback Programme

    Following the decision made by Ipsen's Board of Directors on
December 12, 2006 to put in place a stock options programme totalling
899,500 shares, of which 533,334 are stock options, and following the
relevant authorisation granted by Ipsen's General Assembly on June 2,
2006, the Board of Directors decided on January 25, 2007, in order to
cover these stock options, to allocate up to EUR 21 million to Ipsen'
share buyback programme, which was implemented on June 2, 2006.
Furthermore, on 16 January 2006, the Company had already allocated EUR
2.5 million to this programme in the framework of its liquidity
contract.

    (1) The figures for 2005 are stated on a pro forma basis. The pro
forma consolidated statements present the Group's activity as if the
legal reorganisation of the Group completed in June 2005 had taken
place on 1 January 2002.

    (2) Sales of active ingredients and raw materials.

    (3) In France;, reduction of its reimbursement rate from 35% to
15% as well as a 15% price reduction on the entire veinotonic class
drugs.

    (4) The figures for 2005 are stated on a pro forma basis. The pro
forma consolidated statements present the Group's activity as if the
legal reorganisation of the Group completed in June 2005 had taken
place on 1 January 2002.

    (5) Active ingredients and raw materials

    --30--DC/ps*

    CONTACT: Didier Veron,
             Director, Public Affairs and Corporate Communications
             Tel.: +33 (0)1 44 30 42 38 - Fax: +33 (0)1 44 30 42 04
             E-mail: didier.veron@ipsen.com
             or
             David Schilansky,
             Investor Relations Officer
             Tel.: +33 (0)1 44 30 43 31 - Fax: +33 (0)1 44 30 43 21
             E-mail: david.schilansky@ipsen.com